Got question for Dr Garg, M.D.? Click Here

      888-434-6841

Do You Have Arthritis?

"SmartChoice® Stem Cell Institute has been very helpful to my quality of life. Dr. Garg is one of the best doctors I have ever had and I have seen many." – Codi B.

PROVIDING NON-SURGICAL ALTERNATIVE TO JOINT AND BACK  PROBLEMS

Experience Counts - Located in Jacksonville, Florida, we are the leader in Adult Stem Cell and Platelet-Rich Plasma (PRP) Procedures. We have performed these procedures for more than ten years with over 90 % results and ZERO side effects.

Top Stem Cell Center in the World: Unique Proven Clinical Protocols, over ten years of experience and hundreds of satisfied patients is why people from around the world come to us for their adult stem cell and Platelet-Rich Plasma Procedures. 

FIVE reasons you need to know before you decide. You will see why people around the world choose us over other Clinics.

Glaring Differences

SmartChoice®

Clinic

 

Other Leading Stem Cell Clinics (including Regenexx, Cell surgical Networks and others)

1. Gene and Cellular tests to evaluate your stem cell functions.

YES

NO

2. Use BOTH Bone Marrow and Fat Stem Cells, along with PRP.

YES

NO

3. Process Your Stem Cells with safety and use no dangerous chemicals like collagenase.

YES

NO

4. Use Dynamic Ultrasound Guided Injections for Precision and safety (and NOT use X-Rays that can damage your cells).

YES

NO

5. Improve body functions with proprietary Hormones and Supplements, so you get the best possible clinical outcome.

YES

NO

 

 

At SmartChoice® we believe that cost should not be an obstacle to getting your quality of life back. We put these procedures within reach of most budgets.


Treatment costs less
than you might think.
Learn More

These treatments are already extensively used by people with sports injuries and orthopedic conditions, for faster recovery times and better results.


Over 95% success rate
for joint restoration.
Learn More

Last year, I successfully performed SmartChoice® Procedure on my son, Neil for a ligament injury near his shoulder. Yes, these procedures are safe.


Patient safety is our
number one priority
Learn More

As an alternative to the knee and hip (and other joints) surgery or total joint replacement, SmartChoice® Joint Procedures may help alleviate joint pain, arthritis and other medical condition that caused it with a simple office injection procedure. We encourage the patients to walk the same day and most experience almost no downtime after our procedures whatsoever.

And if you are considering a knee, hip or other joint replacement from arthritis or other medical conditions, you might want to learn about how the adult stem cells and PRP procedures stack up against these risky Orthopedic surgeries.

The conditions we treat may arise from the aging process such as arthritis or from sports and other injuries. We offer regenerative medicine techniques,including your own adult stem cells and Platelet Rich Plasma (PRP) treatments, for relief of pain and other symptoms in the joints. No matter where you are experiencing pain, there is a regenerative technique for your orthopedic and cosmetic needs.

See how our non-surgical, office-based, SmartChoice® Joint Procedures can help your arthritis and other orthopedic conditions.

 

What is The Wear and Tear of Arthritis?

The word Arthritis is derived from Greek - arthro meaning joint, and -itis meaning inflammation. Arthritis is inflammation of one or more joints. A joint is the area where two bones meet.

Often called "wear and tear" arthritis, osteoarthritis (OA) is the most common form of arthritis in the U.S. affecting over 25 million people.

Knee

In most cases, OA involves the breakdown of cartilage. Cartilage normally protects a joint, allowing it to move smoothly. Cartilage also absorbs shock when pressure is placed on the joint, such as when you walk. Without the normal amount of cartilage, the bones rub together, causing pain, swelling (inflammation), and stiffness.

Mostly patients develop OA due to aging and injuries like trauma to the joint or sports injuries.

OA is most commonly found in the Knees, Hips, Hands and fingers and Spine. Wrists, elbows, shoulders, and ankles can also be affected by OA, but this occurs less frequently. When OA is found in these joints, there may have been a history of injury or stress to that joint.

Osteoarthritis is NOT a disease of old age anymore. More and more younger individuals in their 30s and 40s are getting osteoarthritis due to sports and auto accidents.

Sports

Osteoarthritis usually starts in weight-bearing joints like knee. Arthritis causes joint pain, swelling, stiffness, and limited movement. Besides pain, symptoms can also include - Joint swelling, reduced ability to move the joint and stiffness, especially in the morning.

Lifestyle changes are important for osteoarthritis and other types of joint inflammation. Exercise can help relieve stiffness, reduce pain and fatigue, and improve muscle and bone strength. Our health care team can help you design an exercise program that is best for you. Exercise programs may include - Low-impact aerobic activity (also called endurance exercise), Range of motion exercises for flexibility and Strength training for muscle tone.

MEDICAL LITERATURE - PRP AND STEM CELLS IN ARTHRITIS

1.     Treatment of Knee Osteoarthritis with Autologous Mesenchymal Stem Cells:A Pilot Study. Orozco L, Munar A, Soler R, Alberca M, Soler F, Huguet M, Sentís J, Sánchez A, García-Sancho-  J. Transplantation. 2013 May 15.
 
2.     Current clinical therapies for cartilage repair, their limitation and the role of stem cells. Dhinsa BS, Adesida AB. Curr Stem Cell Res Ther. 2012 Mar;7(2):143-8. 2.
 
3.     Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis. Qi Y, Feng G, Yan W.  Mol Biol Rep. 2012 May;39(5):5683-9.
 
4.     Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis. Koh YG, Jo SB, Kwon OR, Suh DS, Lee SW, Park SH, Choi Y.  J. Arthroscopy. 2013 Jan 29.
 
5.     Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Emadedin M, Aghdami N, Taghiyar L, Fazeli R, Moghadasali R, Jahangir S, Farjad R, Baghaban Eslaminejad M. Arch Iran Med. 2012 Jul;15(7):422-8.
 
6.     Developments in stem cells: implications for future joint replacements. Proc Maclaine SE, McNamara LE, Bennett AJ, Dalby MJ, Meek RM. Inst Mech Eng H. 2013 Mar;227(3):275-83.
 
7.     Current surgical options for articular cartilage repair. Peretti GM, Pozzi A, Ballis R, Deponti D, Pellacci F.   Acta Neurochir Suppl. 2011;108:213-9.
 
8.     Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis Qi Y, Feng G, Yan W.   Mol Biol Rep. 2012 May;39(5):5683-9.
 
9.     Prospects of stem cell therapy in osteoarthritis. Roberts, Genever, McCaskie & De Bari; Regen. Med. (2011) 6(3), 351–366).
 
10.  Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review and Meta-analysis. Rutjes AWS, Jüni P, MD; da Costa BR, et al. Ann Intern Med. 2012 Jun 11.

11. Comparative Effectiveness of Platelet-Rich Plasma Injections for Treating Knee Joint Cartilage Degenerative Pathology: A Systematic Review and Meta-analysis. Chang KV, Hung CY, Aliwarga F, Wang TG, Han DS, Chen WS. Arch Phys Med Rehabil. 2013 Nov 27.
 
12.  A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis. Sánchez M, Fiz N, Azofra J, et al.    Arthroscopy. 2012 Aug;28(8):1070-8.
 
13.  Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, Fornasari PM, Giannini S, Marcacci M.  Arthroscopy. 2011 Nov;27(11):1490-501.
 
14.  Treatment of Knee Osteoarthritis with Autologous Mesenchymal Stem Cells: A Pilot Study. Orozco L, Munar A, Soler R, Alberca M, Soler F, Huguet M, Sentís J, Sánchez A, García-Sancho J.  Transplantation. 2013 May 15.
 
15.  Current clinical therapies for cartilage repair, their limitation and the role of stem cells. Dhinsa BS, Adesida AB. Curr Stem Cell Res Ther. 2012 Mar;7(2):143-8.
 
16.  Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis. Qi Y, Feng G, Yan W. Mol Biol Rep. 2012 May;39(5):5683-9.
 
17.  Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M.    Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):472-9.
 
18.  Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid. Spaková T, Rosocha J, Lacko M, et al.  Am J Phys Med Rehabil. 2012 May;91(5):411-7
 
 
19. Therapeutic effectiveness of intra-knee-articular injection of platelet-rich plasma on knee articular cartilage degeneration]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011 Oct;25(10):1192-6.
 
20.  Growth factors in the treatment of early osteoarthritis. Civinini R, Nistri L, Martini C, Redl B, Ristori G, Innocenti M. Clin Cases Miner Bone Metab. 2013 Jan;10(1):26-9.
 
21.  Treatment of knee chondropathy with platelet rich plasma.Preliminary results at 6 months of follow-up with only one injection. Torrero JI, Aroles F, Ferrer D.   J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2 Suppl 1):71S-78S.
 
22.  Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: A proof-of-concept clinical trial. Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Stem Cells. 2014 Jan 21.
 
23.  Mesenchymal stem cells in joint disease and repair. Barry F, Murphy M. Nat Rev Rheumatol. 2013 Jul 23.
 
24.  Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells:A Pilot Study. Orozco L, Munar A, Soler R, et al. Transplantation. 2013 Jun 27;95(12):1535-1541.
 
25. Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease.Sampson S1, Botto-van Bemden AAufiero D Phys Sportsmed. 2013 Sep;41(3):7-18.
 
26.  Clinical outcome of autologous bone marrow aspirates concentrate (BMAC) injection in degenerative arthritis of the knee, Jae-Do KimGun Woo LeeGu Hee JungCheung Kue KimTaehun KimJin Hyung ParkSeong Sook ChaYoung-Bin YouEuropean Journal of Orthopaedic Surgery & TraumatologyJanuary 2014
 
27.  Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series.Hauser RA1, Orlofsky A.   Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 4;6:65-72. 
 
28.  Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. Pascual-Garrido C, et al. Stem Cells Int. 2012; Epub 2011 Dec 18.
 
29.  Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients. Hendrich C1, Franz EWaertel GKrebs RJäger M.  Orthop Rev (Pavia). 2009 Oct 10;1(2):e32
 
30. Stem cells and cartilage development: complexities of a simple tissue. Hollander AP, Dickinson SC, Kafienah W, Stem Cells 2010, 28:1992-1996. 
 
31.  Cartilage tissue engineering: towards a biomaterial assisted mesenchymal stem cell therapy. Vinatier C, Bouffi C, Merceron C, Gordeladze J, Brondello JM, Jorgensen C, Weiss P, Guicheux J, Noel D.  Curr Stem Cell Res Ther 2009, 4:318-329.
 
 32. REVIEW - Mesenchymal stem cells in arthritic diseases. Faye H Chen and Rocky S Tuan,  Arthritis Research & Therapy 2008, 10:223
 
33. Mesenchymal stem cells for cartilage repair in osteoarthritis. Pawan K Gupta1, Anjan K Das2, Anoop Chullikana1 and Anish S Majumdar. Stem Cell Research & Therapy 2012, 3:25 
 
34.  Stem Cell Prolotherapy in Regenerative Medicine -Background, Theory and Protocols,  Donna D. Alderman, DO, Robert W. Alexander, MD, DMD, FICS, Gerald R. Harris, DO, Patrick C. Astourian, MS, PA-C, JOURNAL of PROLOTHERAPY | VOLUME 3, ISSUE 3 | AUGUST 2011
 
35.  Chondrogenesis and cartilage tissue engineering: the longer road to technology development.  Mahmoudifar N1, Doran PM.  Trends Biotechnol. 2012 Mar;30(3):166-76.
 
36. Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives. Andre F. Steinert, Lars Rackwitz, Fabian Gilbert, Ulrich Nöth and Rocky S. Tuan. Stem Cells Trans Med 2012, 1:237-247.

37.  Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.  Caplan AI ,  J Cell Physiol 2007, 213:341-347.
 
38.  Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Hass R, Kasper C, Bohm S, Jacobs R  - Cell Commun Signal 2011, 9:12
 
39.  Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the futurehold? Singh A Jasvinder. BMC Medicine 2012, 10:44
 
40. Marrow stromal cells as stem cells for nonhematopoietic tissues.  Prockop DJScience. 1997 Apr 4;276(5309):71-4.
 
41.  Multilineage potential of adult human mesenchymal stem cells. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR . Science 1999,284:143-147.
 
42. Stem cell therapy for cartilage regeneration in osteoarthritis.Koelling S1, Miosge NExpert Opin Biol Ther. 2009 Nov;9(11):1399-405.
 
43. Intraarticular treatments for osteoarthritis: new perspectives. Chevalier X.Curr Drug Targets. 2010 May;11(5):546-60.
 
44.  Mesenchymal stem cell-based HLA-independent cell therapy for tissue engineering of bone and cartilageNiemeyer P1, Krause UKasten PKreuz PCHenle PSüdkam NPMehlhorn A.  Curr Stem Cell Res Ther. 2006 Jan;1(1):21-7.
 
45.  Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. Wakitani S1, Nawata MTensho KOkabe TMachida HOhgushi H.  J Tissue Eng Regen Med. 2007 Jan-Feb;1(1):74-9.
 
46.  Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Nejadnik H1, Hui JHFeng Choong EPTai BCLee EH.  Am J Sports Med. 2010 Jun;38(6):1110-6.
 
47. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Davatchi F1, Abdollahi BSMohyeddin MShahram FNikbin B.  Int J Rheum Dis. 2011 May;14(2):211-5.
 
48.  Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Emadedin M1, Aghdami NTaghiyar LFazeli RMoghadasali RJahangir SFarjad RBaghaban Eslaminejad M.  Arch Iran Med. 2012 Jul;15(7):422-8.
 
49.  Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two cases reportKasemkijwattana C1, Hongeng SKesprayura SRungsinaporn VChaipinyo KChansiri K.   J Med Assoc Thai. 2011 Mar;94(3):395-400.
 
50.  Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Centeno CJ1, Busse DKisiday JKeohan CFreeman MKarli D.  Pain Physician. 2008 May-Jun;11(3):343-53.
 
51.  The Clinical Use of Human Culture-Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects: A Pilot Study and Preliminary Results. Haleem AM1, Singergy AASabry DAtta HMRashed LAChu CREl Shewy MTAzzam AAbdel Aziz MT.   Cartilage. 2010 Oct;1(4):253-261.

 

Back to Top